Hepatopancreatobiliary Oncology: Understanding Liver, Pancreatic, and Biliary Tract Cancers & the Latest Treatment Advances with Dr. Prosenjit Das
Introduction
Hepatopancreatobiliary (HPB) cancers, affecting the liver, pancreas, and biliary tract, are among the most aggressive malignancies. Early detection is often difficult, making expert care and advanced treatments essential. Dr. Prosenjit Das, a leading specialist in HPB oncology, provides crucial insights into these cancers, their symptoms, diagnostic approaches, and the latest treatment advancements.
Understanding HPB Cancers
1. Liver Cancer (Hepatocellular Carcinoma – HCC)
Liver cancer often develops due to chronic liver diseases.
Risk factors include:
- Chronic hepatitis B & C infections
- Cirrhosis
- Heavy alcohol consumption
- Non-alcoholic fatty liver disease (NAFLD)
2. Pancreatic Cancer
Known for its aggressive nature, pancreatic cancer is often diagnosed late.
Risk factors include:
- Smoking
- Chronic pancreatitis
- Diabetes
- Family history of pancreatic cancer
3. Biliary Tract Cancer (Cholangiocarcinoma & Gallbladder Cancer)
These cancers affect the bile ducts and gallbladder.
Risk factors include:
- Chronic gallstones
- Primary sclerosing cholangitis
- Liver fluke infections
Symptoms of HPB Cancers
- Persistent abdominal pain
- Unexplained weight loss
- Jaundice (yellowing of skin and eyes)
- Nausea and vomiting
- Dark urine and pale stools
Diagnosis & Staging
Timely diagnosis is critical for effective treatment. Common diagnostic methods include:
- Blood tests: Tumor markers like AFP (Liver) & CA 19-9 (Pancreas/Biliary).
- Imaging: CT scan, MRI, and PET scans for tumor assessment.
- Biopsy: Confirms cancer type and stage.
- Endoscopic Ultrasound (EUS): Evaluates pancreatic and bile duct tumors.
Advanced Treatment Approaches in HPB Oncology
1. Surgery for Early-Stage Cancers
- Liver Resection & Transplantation for localized liver tumors.
- Whipple Procedure for pancreatic head tumors.
- Biliary Bypass Surgery to relieve bile duct obstruction.
2. Minimally Invasive & Targeted Therapies
- Laparoscopic & Robotic Surgery for precision and faster recovery.
- Radiofrequency Ablation (RFA) & Transarterial Chemoembolization (TACE) for liver tumors.
- Targeted Therapy: Sorafenib for liver cancer, Erlotinib for pancreatic cancer.
3. Immunotherapy & Chemotherapy
- Immunotherapy boosts the body’s immune response to fight cancer.
- Chemotherapy controls tumor growth and improves survival rates.
4. Radiation Therapy
- Stereotactic Body Radiation Therapy (SBRT) for localized tumors.
- Proton Therapy for precise radiation while minimizing damage to healthy tissues.
Conclusion
HPB cancers require early detection and a multidisciplinary treatment approach. Under the expertise of Dr. Prosenjit Das, patients receive advanced, personalized cancer care. If you or a loved one experience symptoms, consult a specialist for early intervention and improved outcomes.